![]() We are also developing new imaging technologies to simultaneously monitor cellular concentrations of multiple lipids and the activities of lipid-binding proteins in live cells and tissues. They can be also used as biomarkers for various human diseases. These sensors will help us elucidate the cellular dynamics of these lipids and discover their new cellular activities. We are currently developing specific fluorescence-based sensors for a wide variety of lipids. Our newly developed in situ quantitative lipid imaging technology ( Nature Chemistry, 2011) has not only demonstrated high-resolution spatiotemporal dynamics of various lipids but also provided new insight into how lipid molecules regulate complex cellular processes. Lipids are ubiquitous and dynamic regulatory molecules and their biological functions depend on their subcellular locations and local concentrations. Body (1) Seeing is believing and it is numbers that matter ![]()
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